The 10 Best Pharmacies in South Dakota — 2026

We compared all 129 pharmacies in South Dakota on the data that matters: services offered, posted hours, and how easy each one is to reach. No pay-to-play — this ranking comes straight from the listings data, updated November 2026.

#1 · CVS PharmacyRapid City

(800) 746-7287 Website View listing

#2 · Dakotamart PharmacyPierre

(605) 224-7396 Website View listing

#3 · Lewis DrugHuron

(605) 352-6495 Website View listing

#4 · Plaza PharmacyAberdeen

(605) 225-1945 Website View listing

#5 · Carson DrugCuster

(605) 673-2225 Website View listing

#6 · Parkston DrugParkston

(605) 928-3125 Website View listing

#7 · Monument Health Home+ PharmacySpearfish

(605) 717-8741 Website View listing

#8 · Caretrends PharmacySioux Falls

(605) 338-9383 Website View listing

#9 · Cornwell DrugWebster

(605) 345-3351 Website View listing

#10 · Dakota Country PharmacyPhilip

(605) 859-2833 Website View listing

Run one of these businesses? You earned this spot — email contact@pharmacyatlas.com for your free “Top Pharmacies in South Dakota” badge to put on your site, and we’ll make sure your listing stays accurate.
How we rank: every listing earns points for listed services (compounding, specialty pharmacy), posted hours, and working contact details. The ranking is recalculated with every data update.